Fusarium rhinosinusitis post chimeric antigen receptor T-cell therapy

Supavit Chesdachai; Natalia E Castillo Almeida; Isin Y Comba; Prasuna Muppa; Matthew J Thoendel

doi:10.1016/j.idcr.2021.e01088

Fusarium rhinosinusitis post chimeric antigen receptor T-cell therapy

IDCases. 2021 Mar 26:24:e01088. doi: 10.1016/j.idcr.2021.e01088. eCollection 2021.

Authors

Supavit Chesdachai¹, Natalia E Castillo Almeida¹, Isin Y Comba¹, Prasuna Muppa², Matthew J Thoendel¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Abstract

Chimeric antigen receptor T-cell (CAR-T) therapy is a novel treatment for various types of hematologic malignancy. We presented a case of refractory diffuse large B cell lymphoma patient who developed acute invasive fungal rhinosinusitis (AIFR) from Fusarium species after CAR-T therapy. Our photos illustrated the classic clinical, endoscopic, and histopathologic findings of AIFR.

Keywords: Chimeric antigen receptor; Fusarium; Invasive fungal rhinosinusitis; Neutropenia.