KIBRA connects Hippo signaling and cancer

Srikanth Swamy Swaroop B; Rahul Kanumuri; Inemai Ezhil; Jagadeesh Kumar Naidu Sampangi; Joachim Kremerskothen; Suresh Kumar Rayala; Ganesh Venkatraman

doi:10.1016/j.yexcr.2021.112613

KIBRA connects Hippo signaling and cancer

Exp Cell Res. 2021 Jun 15;403(2):112613. doi: 10.1016/j.yexcr.2021.112613. Epub 2021 Apr 24.

Authors

Srikanth Swamy Swaroop B¹, Rahul Kanumuri¹, Inemai Ezhil², Jagadeesh Kumar Naidu Sampangi³, Joachim Kremerskothen⁴, Suresh Kumar Rayala⁵, Ganesh Venkatraman⁶

Affiliations

¹ Department of Human Genetics, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, Tamil Nadu, India; Department of Biotechnology, Indian Institute of Technology, Madras, Chennai, 600036, Tamil Nadu, India.
² Department of Biotechnology, Indian Institute of Technology, Madras, Chennai, 600036, Tamil Nadu, India.
³ Department of Human Genetics, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, Tamil Nadu, India.
⁴ Department of Nephrology, Hypertension and Rheumatology, University Hospital Münster, Münster, Germany.
⁵ Department of Biotechnology, Indian Institute of Technology, Madras, Chennai, 600036, Tamil Nadu, India. Electronic address: rayala@iitm.ac.in.
⁶ Department of Human Genetics, Faculty of Biomedical Sciences & Technology, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, Tamil Nadu, India. Electronic address: ganeshv@sriramachandra.edu.in.

PMID: 33901448
DOI: 10.1016/j.yexcr.2021.112613

Abstract

The Hippo signaling pathway is a tumor suppressor pathway that plays an important role in tissue homeostasis and organ size control. KIBRA is one of the many upstream regulators of the Hippo pathway. It functions as a tumor suppressor by positively regulating the core Hippo kinase cascade. However, there are accumulating shreds of evidence showing that KIBRA has an oncogenic function, which we speculate may arise from its functions away from the Hippo pathway. In this review, we have attempted to provide an overview of the Hippo signaling with a special emphasis on evidence showing the paradoxical role of KIBRA in cancer.

Keywords: Cancer; Cell signalling; Hippo; KIBRA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adherens Junctions / metabolism
Adherens Junctions / ultrastructure
Animals
Cell Cycle Proteins / genetics
Cell Cycle Proteins / metabolism
Cell Line, Tumor
Extracellular Signal-Regulated MAP Kinases / genetics
Extracellular Signal-Regulated MAP Kinases / metabolism
Focal Adhesions / metabolism
Focal Adhesions / ultrastructure
Gene Expression Regulation, Neoplastic*
Hepatocyte Growth Factor / genetics
Hepatocyte Growth Factor / metabolism
Hippo Signaling Pathway
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Intracellular Signaling Peptides and Proteins / metabolism
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology
Protein Serine-Threonine Kinases / genetics*
Protein Serine-Threonine Kinases / metabolism
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism
Serine-Threonine Kinase 3
Signal Transduction / genetics*
Transcription Factors / genetics
Transcription Factors / metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism

Substances

Cell Cycle Proteins
Intracellular Signaling Peptides and Proteins
Proto-Oncogene Proteins
Transcription Factors
Transcriptional Coactivator with PDZ-Binding Motif Proteins
Tumor Suppressor Proteins
WWC1 protein, human
WWTR1 protein, human
YY1AP1 protein, human
Hepatocyte Growth Factor
LATS1 protein, human
LATS2 protein, human
Protein Serine-Threonine Kinases
STK3 protein, human
Serine-Threonine Kinase 3
Extracellular Signal-Regulated MAP Kinases