Characteristics and Outcomes of Children With Cystic Fibrosis Hospitalized With Cirrhosis in the United States

Am J Gastroenterol. 2021 Aug 1;116(8):1734-1737. doi: 10.14309/ajg.0000000000001275.

Abstract

Introduction: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States.

Methods: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database.

Results: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis. Hepatic encephalopathy was significantly associated with death in children with cirrhosis.

Discussion: Future interventions should be designed to support children with CF who have cirrhosis to improve clinical outcomes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / mortality
  • Female
  • Hospital Charges
  • Hospital Mortality
  • Hospitalization*
  • Humans
  • Length of Stay
  • Liver Cirrhosis / epidemiology*
  • Liver Cirrhosis / mortality
  • Male
  • United States / epidemiology