Three is a crowd: Clinical outcomes of a twice daily versus a thrice daily metronidazole dosing strategy from a multicenter study

Anaerobe. 2021 Oct:71:102378. doi: 10.1016/j.anaerobe.2021.102378. Epub 2021 May 7.

Abstract

This was a multicenter, retrospective study of patients with anaerobic bacteremia comparing metronidazole 500 mg every 8 h versus 500 mg every 12 h. Of 782 patients reviewed, 85 met inclusion criteria. There was no significant difference in mortality, length of stay, or escalation of therapy between dosing strategies.

Keywords: 12 hour; Anaerobic bacteremia; Dose; Metronidazole.

Publication types

  • Clinical Study
  • Multicenter Study

MeSH terms

  • Aged
  • Anti-Bacterial Agents / administration & dosage*
  • Bacteremia / drug therapy*
  • Bacteremia / mortality
  • Bacteria, Anaerobic / classification
  • Bacteria, Anaerobic / drug effects
  • Bacteria, Anaerobic / genetics
  • Bacteria, Anaerobic / isolation & purification
  • Drug Administration Schedule
  • Female
  • Humans
  • Length of Stay
  • Male
  • Metronidazole / administration & dosage*
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Metronidazole