Cardiovascular research is fundamentally important to human health, and research progress in this field could not be overemphasized. Recently we were encouraged by the editors of Vessels Plus to invite vascular biologists to submit their research and review articles to the special issue on "Vascular remodeling 2018: the updates" that would show up some overview of recent research from biomedical vascular science. In this special issue, we assembled five reviews and one original research paper devoted various areas of vascular biology and denoted recent advances in clinically relevant cellular and signaling mechanisms in vascular remodeling.