The Importance of Early Recognition of KSHV-Mediated Syndromes: A Case Report

Am J Med. 2021 Oct;134(10):e503-e506. doi: 10.1016/j.amjmed.2021.04.015. Epub 2021 May 11.

Abstract

Acute Kaposi sarcoma herpes virus (KSHV)-associated inflammatory diseases are under-recognized. We describe a woman with HIV presenting with disseminated KS and refractory shock, concerning for KSHV-associated inflammatory cytokine syndrome (KICS) versus multicentric Castelman’s disease (MCD). High-quality research and clinician education are needed to improve prognosis of patients with KSHV-associated diseases.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antiviral Agents / therapeutic use
  • Diagnosis, Differential
  • Doxorubicin / therapeutic use
  • Drug Therapy, Combination
  • Early Diagnosis
  • Female
  • Herpesviridae Infections / diagnosis*
  • Herpesviridae Infections / drug therapy*
  • Herpesviridae Infections / virology
  • Herpesvirus 8, Human*
  • Humans
  • Immunologic Factors / therapeutic use
  • Middle Aged
  • Rituximab / therapeutic use
  • Syndrome

Substances

  • Antiviral Agents
  • Immunologic Factors
  • Rituximab
  • Doxorubicin