Invasive Hormographiella aspergillata infection in patients with acute myeloid leukemia: Report of two cases successfully treated and review of the literature

Jonathan Tschopp; Jean Yannis Perentes; Catherine Beigelman-Aubry; Sabina Berezowska; Alban Lovis; Olivier Spertini; Pierre-Yves Bochud; Frederic Lamoth

doi:10.1016/j.mmcr.2021.03.008

Invasive Hormographiella aspergillata infection in patients with acute myeloid leukemia: Report of two cases successfully treated and review of the literature

Med Mycol Case Rep. 2021 Apr 14:32:68-72. doi: 10.1016/j.mmcr.2021.03.008. eCollection 2021 Jun.

Authors

Jonathan Tschopp¹, Jean Yannis Perentes², Catherine Beigelman-Aubry³, Sabina Berezowska⁴, Alban Lovis⁵, Olivier Spertini⁶, Pierre-Yves Bochud¹, Frederic Lamoth^{1

7}

Affiliations

¹ Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
² Department of Thoracic Surgery, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
³ Department of Radiology and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
⁴ Institute of Pathology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
⁵ Department of Pulmonology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
⁶ Department of Hematology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
⁷ Institute of Microbiology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.

Abstract

Hormographiella aspergillata is a rare cause of invasive mold infection, mostly described in patients with hematological malignancies. We describe two cases of invasive H. aspergillata infections in patients with acute myeloid leukemia, successfully managed with complete surgical resection of the lesions and antifungal therapy of voriconazole alone or liposomal amphotericin B, followed by voriconazole, highlighting the key role of a multidisciplinary approach for the treatment of this rare and severe invasive mold infection.

Keywords: Amphotericin B; Coprinopsis cinerea; Fungal PCR; Hormographiella aspergillata; Voriconazole.