Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy

Elizabeth S Silagi; Rosalind A Segal

doi:10.1093/brain/awab196

Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy

Brain. 2021 Jul 28;144(6):1621-1623. doi: 10.1093/brain/awab196.

Authors

Elizabeth S Silagi^{1

2}, Rosalind A Segal^{1

2}

Affiliations

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

Abstract

This scientific commentary refers to ‘Paclitaxel increases axonal localization and vesicular trafficking of Na_v1.7’ by Akin et al. (doi: 10.1093/brain/awab113).

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antineoplastic Agents, Phytogenic*
Humans
Paclitaxel / adverse effects
Peripheral Nervous System Diseases* / chemically induced
Peripheral Nervous System Diseases* / genetics

Substances

Antineoplastic Agents, Phytogenic
Paclitaxel

Abstract

Publication types

MeSH terms

Substances

Grants and funding