Standardized Uptake Value Illuminates Tumor Inflammation and Treatment Response

Casey W Williamson; Dmitriy Zamarin; Jyoti Mayadev

doi:10.1158/1078-0432.CCR-21-1350

Standardized Uptake Value Illuminates Tumor Inflammation and Treatment Response

Clin Cancer Res. 2021 Aug 1;27(15):4136-4138. doi: 10.1158/1078-0432.CCR-21-1350. Epub 2021 May 20.

Authors

Casey W Williamson¹, Dmitriy Zamarin², Jyoti Mayadev³

Affiliations

¹ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California.
² Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California. jmayadev@ucsd.edu.

PMID: 34016640
DOI: 10.1158/1078-0432.CCR-21-1350

Abstract

Maximum standardized uptake value (SUV_max) on PET imaging is prognostic in cervical cancer. It was recently demonstrated that low pretreatment SUV_max is associated with superior prognosis and is correlated with decreased inflammatory signaling and myeloid-derived cell infiltration into the tumor microenvironment, potentially identifying susceptibility to targeted therapies.See related article by Floberg et al., p. 4245.

Publication types

Comment

MeSH terms

Female
Fluorodeoxyglucose F18*
Humans
Inflammation
Positron-Emission Tomography
Prognosis
Radiopharmaceuticals
Tumor Microenvironment
Uterine Cervical Neoplasms*

Substances

Radiopharmaceuticals
Fluorodeoxyglucose F18