Abstract
A simple and feasible atom-precise biotinylated Cu(i) complex, which can catalyze H2O2 overexpressed commonly in the tumor microenvironment to produce ˙OH through a Fenton-like reaction, was prepared and employed as an effective agent for tumor-targeted chemodynamic therapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Biotinylation
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Catalysis
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Copper / chemistry
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Copper / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Hydrogen Peroxide / chemistry
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Hydrogen Peroxide / metabolism
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Mice
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Molecular Structure
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Neoplasms, Experimental / drug therapy
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / pathology
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Tumor Microenvironment / drug effects
Substances
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Antineoplastic Agents
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Coordination Complexes
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Copper
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Hydrogen Peroxide