Adenocarcinoma of High-Grade Patterns Associated with Distinct Outcome of First-Line Chemotherapy or EGFR-TKIs in Patients of Relapsed Lung Cancer

Xiaofei Yu; Zhengwei Dong; Wanying Wang; Shiqi Mao; Yingying Pan; Yiwei Liu; Shuo Yang; Bin Chen; Chunyan Wang; Xuefei Li; Chao Zhao; Keyi Jia; Chuchu Shao; Chunyan Wu; Shengxiang Ren; Caicun Zhou

doi:10.2147/CMAR.S302545

Adenocarcinoma of High-Grade Patterns Associated with Distinct Outcome of First-Line Chemotherapy or EGFR-TKIs in Patients of Relapsed Lung Cancer

Cancer Manag Res. 2021 May 17:13:3981-3990. doi: 10.2147/CMAR.S302545. eCollection 2021.

Authors

Xiaofei Yu^#¹, Zhengwei Dong^#², Wanying Wang¹, Shiqi Mao¹, Yingying Pan¹, Yiwei Liu¹, Shuo Yang¹, Bin Chen¹, Chunyan Wang¹, Xuefei Li³, Chao Zhao³, Keyi Jia¹, Chuchu Shao¹, Chunyan Wu², Shengxiang Ren¹, Caicun Zhou¹

Affiliations

¹ Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
² Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.
³ Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People's Republic of China.

^# Contributed equally.

Abstract

Purpose: High-grade patterns (micropapillary/solid/complex gland) are associated with a higher recurrence rate and shorter disease-free survival. Thus far, it remains unclear whether the efficacy of first-line anticancer therapy is different from that of the other adenocarcinoma subgroups for patients with high-grade patterns. The study aimed to investigate the association between an adenocarcinoma with high-grade patterns with the outcomes of first-line treatment in patients with lung cancer.

Patients and methods: Patients with a high-grade pattern adenocarcinoma (more than 20% of micropapillary/solid components/complex glandular patterns) were retrospectively analyzed between June 2015 and June 2017. Patients' clinical characteristics and treatment outcomes were compared with those of the remaining control adenocarcinoma subgroups.

Results: In total, 239 patients with adenocarcinoma, including 115 (48.1%) high-grade patterns and 124 (51.9%) control groups, were enrolled. Patients' clinical characteristics such as age, sex, smoking status, and stage were similar between the two groups. Among them, 108 patients received first-line chemotherapy, and 131 received epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). In the chemotherapy group, adenocarcinoma of high-grade patterns had a significantly lower objective response rate (ORR; 15.6% vs 36.4%, P=0.045), shorter progression-free survival (PFS; median 4.1 vs 5.4 months, P=0.007) and overall survival (OS, median 19.6 vs 23.8 months, P=0.048) compared with the control group. As for these treated with EGFR-TKIs, a similar ORR (70.7% vs 72.1%, P=0.703), PFS (median 11.3 vs 13.9 months, P=0.065) and OS (median 34.1 vs 29.6%, p=0.575) were observed between these two groups.

Conclusion: An adenocarcinoma with high-grade patterns is associated with inferior outcomes to first-line chemotherapy in relapsed lung cancer. Patients who received chemotherapy had a significantly shorter PFS and OS and lower ORR than control subjects, while there was no difference in the EGFR-TKI cohort. This study is the first to report the distribution of adenocarcinoma with high-grade patterns.

Keywords: EGFR-TKIs; adenocarcinoma; chemotherapy; micropapillary; solid.

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (No. 81772467 to S.R., No. 81972167 to S.R.), Shanghai Pujiang Program (No. 2019PJD048 to S.R.), Shanghai Shenkang Hospital Development Center (No. SHDC12019133 to S.R.) and the Backbone Program of Shanghai Pulmonary Hospital (NO. FKGG1802).