Fantastic IgA plasma cells and where to find them

Abstract

IgA is produced in large quantities at mucosal surfaces by IgA⁺ plasma cells (PC), protecting the host from pathogens, and restricting commensal access to the subepithelium. It is becoming increasingly appreciated that IgA⁺ PC are not constrained to mucosal barrier sites. Rather, IgA⁺ PC may leave these sites where they provide both host defense and immunoregulatory function. In this review, we will outline how IgA⁺ PC are generated within the mucosae and how they subsequently migrate to their "classical" effector site, the gut lamina propria. From there we provide examples of IgA⁺ PC displacement from the gut to other parts of the body, referencing examples during homeostasis and inflammation. Lastly, we will speculate on mechanisms of IgA⁺ PC displacement to other tissues. Our aim is to provide a new perspective on how IgA⁺ PC are truly fantastic beasts of the immune system and identify new places to find them.

Keywords: IgA; IgA plasma cells (PC); Peyer's patches (PP); autoimmune disease; bone marrow (BM); intestinal lamina propria (LP); mesenteric lymph nodes (MLN).