My Treatment Approach to Giant Cell Arteritis

Mayo Clin Proc. 2021 Jun;96(6):1530-1545. doi: 10.1016/j.mayocp.2021.02.013.

Abstract

Giant cell arteritis (GCA) is the most common primary systemic vasculitis in adults 50 years or older. Expanded use of advanced arterial imaging has assisted both in the diagnosis of GCA and recognition of disease subsets. Although glucocorticoids have been the mainstay of treatment for almost 7 decades, new therapeutic options have emerged. This review aims to provide the clinician with a pragmatic approach to evaluating and managing patients with GCA while also addressing recent diagnostic and therapeutic developments.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Giant Cell Arteritis / diagnosis*
  • Giant Cell Arteritis / diagnostic imaging
  • Giant Cell Arteritis / drug therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Methotrexate / therapeutic use
  • Remission Induction / methods

Substances

  • Antibodies, Monoclonal, Humanized
  • Glucocorticoids
  • tocilizumab
  • Methotrexate