Catalytic enantioselective construction of vicinal quaternary carbon stereocenters

Feng Zhou; Lei Zhu; Bo-Wen Pan; Yang Shi; Yun-Lin Liu; Jian Zhou

doi:10.1039/d0sc03249b

Catalytic enantioselective construction of vicinal quaternary carbon stereocenters

Chem Sci. 2020 Jul 28;11(35):9341-9365. doi: 10.1039/d0sc03249b.

Authors

Feng Zhou¹, Lei Zhu², Bo-Wen Pan³, Yang Shi³, Yun-Lin Liu⁴, Jian Zhou^{1

5}

Affiliations

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University Shanghai 200062 P. R. China fzhou@chem.ecnu.edu.cn jzhou@chem.ecnu.edu.cn.
² School of Chemistry and Materials Science, Hubei Engineering University Hubei 432000 P. R. China Lei.zhu@hbeu.edu.cn.
³ School of Pharmaceutical, Guizhou University of Traditional Chinese Medicine Guiyang 550002 P. R. China.
⁴ School of Chemistry and Chemical Engineering, Guangzhou University Guangzhou 510006 P. R. China.
⁵ State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai 200032 P. R. China.

Abstract

This review summarizes the advances in the catalytic enantioselective construction of vicinal quaternary carbon stereocenters, introduces major synthetic strategies and discusses their advantages and limitations, highlights the application of known protocols in the total synthesis of natural products, and outlines the synthetic opportunities.

Publication types

Review