Surgical treatment of liver and kidney metastasis from an adenoid cystic carcinoma of the submandibular gland: case report

Tumori. 2021 Dec;107(6):NP87-NP90. doi: 10.1177/03008916211021664. Epub 2021 Jun 7.

Abstract

Introduction: Adenoid cystic carcinomas (ACCs) account for 10% of all malignant salivary tumours. They are slow-growing but locally aggressive. Reports of liver and renal metastases are rare.

Case description: A 58-year-old woman who had undergone resection of a left submandibular ACC in 1995 was referred to our centre for follow-up in 2018. A computed tomography scan revealed two lesions: one on segment six of the liver and the other on a kidney. A hepatic wedge resection and right nephrectomy were performed. The postoperative course was uneventful. At 2-year follow-up, the patient was alive and well with no evidence of disease.

Conclusion: Management of ACC is a therapeutic challenge because of its tendency for distant metastases. The literature recommends regular follow-up imaging and radical surgical treatment but specific guidelines for the approach to recurrence are lacking.

Keywords: ACC; Hepatopancreatobiliary surgery; liver metastases; oncologic surgery.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Carcinoma, Adenoid Cystic / diagnosis
  • Carcinoma, Adenoid Cystic / pathology*
  • Carcinoma, Adenoid Cystic / therapy
  • Combined Modality Therapy
  • Disease Management
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / secondary*
  • Kidney Neoplasms / surgery*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery*
  • Middle Aged
  • Submandibular Gland Neoplasms / diagnosis
  • Submandibular Gland Neoplasms / pathology*
  • Submandibular Gland Neoplasms / therapy
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Ultrasonography