Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure

Pediatr Infect Dis J. 2021 Jul 1;40(7):e259-e262. doi: 10.1097/INF.0000000000003169.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 infection is an infrequent and poorly understood illness. It can present as severe multiorgan failure in children, potentially lethal. Immunomodulation is the empiric treatment because a dysregulated immune response is the primary pathophysiologic mechanism. We present an infant with severe MIS-C, refractory to usual treatment, successfully treated with plasmapheresis.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 / therapy*
  • Child, Preschool
  • Female
  • Humans
  • Immunomodulation*
  • Multiple Organ Failure / immunology*
  • Multiple Organ Failure / therapy*
  • Plasma Exchange*
  • Systemic Inflammatory Response Syndrome / therapy*
  • Treatment Outcome

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related