The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Randa M Breikaa; Brenda Lilly

doi:10.3389/fcvm.2021.681948

The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Front Cardiovasc Med. 2021 May 26:8:681948. doi: 10.3389/fcvm.2021.681948. eCollection 2021.

Authors

Randa M Breikaa^{1

2}, Brenda Lilly^{1

3}

Affiliations

¹ Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States.
² Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, United States.
³ Department of Pediatrics, The Ohio State University, Columbus, OH, United States.

Abstract

COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.

Keywords: COVID-19; cardiovascular; cardiovascular disease; notch signaling pathway; vascular biology.

Publication types

Review

Abstract

Publication types

Grants and funding