Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis

Jean K Ho; Frank Moriarty; Jennifer J Manly; Eric B Larson; Denis A Evans; Kumar B Rajan; Elizabeth M Hudak; Lamiaa Hassan; Enwu Liu; Nobuyuki Sato; Naoyuki Hasebe; Danielle Laurin; Pierre-Hugues Carmichael; Daniel A Nation

doi:10.1161/HYPERTENSIONAHA.121.17049

Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis

Hypertension. 2021 Sep;78(3):629-643. doi: 10.1161/HYPERTENSIONAHA.121.17049. Epub 2021 Jun 21.

Authors

Jean K Ho¹, Frank Moriarty^{2

3}, Jennifer J Manly⁴, Eric B Larson⁵, Denis A Evans⁶, Kumar B Rajan⁶, Elizabeth M Hudak⁷, Lamiaa Hassan⁸, Enwu Liu⁹, Nobuyuki Sato¹⁰, Naoyuki Hasebe¹⁰, Danielle Laurin¹¹, Pierre-Hugues Carmichael¹¹, Daniel A Nation^{1

12}

Affiliations

¹ Institute for Memory Impairments and Neurological Disorders (J.K.H., D.A.N.), University of California, Irvine.
² School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin (F.M.).
³ The Irish Longitudinal Study on Ageing, Trinity College Dublin, Ireland (F.M.).
⁴ Department of Neurology, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York (J.J.M.).
⁵ Kaiser Permanente Washington Health Research Institute, Seattle, WA (E.B.L.).
⁶ Department of Internal Medicine, Rush University Medical Center, Chicago, IL (D.A.E., K.B.R.).
⁷ Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa (E.M.H.).
⁸ Institute of Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Saxony-Anhalt, Germany (L.H.).
⁹ Mary MacKillop Institute for Health Research, Australian Catholic University (E.L.).
¹⁰ Department of Cardiovascular Medicine, Asahikawa Medical University, Japan (N.S., N.H.).
¹¹ Centre d'excellence sur le vieillissement de Québec, Centre de recherche du CHU de Québec and VITAM-Centre de recherche en santé durable, Canada (D.L., P-H.C.).
¹² Department of Psychological Science (D.A.N.), University of California, Irvine.

Abstract

[Figure: see text].

Keywords: angiotensin converting enzyme inhibitors; angiotensin receptor blockers; blood-brain barrier; cognition; dementia; hypertension; renin-angiotensin system.

Publication types

Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Antihypertensive Agents / pharmacology*
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects*
Blood-Brain Barrier / drug effects*
Cognition / drug effects*
Humans
Hypertension / drug therapy
Renin-Angiotensin System / drug effects*

Substances

Antihypertensive Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding