How to switch disease-modifying treatments in multiple sclerosis: Guidelines from the French Multiple Sclerosis Society (SFSEP)

Mult Scler Relat Disord. 2021 Aug:53:103076. doi: 10.1016/j.msard.2021.103076. Epub 2021 Jun 10.

Abstract

Background: Today, there are no recommendations on switching disease-modifying treatments (DMTs) in multiple sclerosis (MS).

Objectives: To establish guidelines on switching DMTs MS.

Methods: A Steering Committee composed of seven MS experts from the French Group for Recommendations in Multiple Sclerosis (France4MS) defined 15 proposals. These proposals were then submitted to a Rating Group, composed of 48 French MS experts, for evaluation. The proposals were classified as 'appropriate', 'inappropriate' or 'uncertain'.

Results: Switching from a first-line therapy to another first-line therapy or a second-line therapy could be done without a washout period. Switching from a second-line therapy to a first-line therapy could be done without a washout period with fingolimod or natalizumab, after 3 months with ocrelizumab or mitoxantrone, and, if disease activity occurs with alemtuzumab or cladribine. The switch from a second-line therapy to another second-line therapy could be done after a washout period of 1 month with fingolimod or natalizumab, after 3 months with ocrelizumab, after 6 months with mitoxantrone, and, if disease activity occurs, with alemtuzumab or cladribine.

Conclusion: This expert consensus approach provides physicians with some guidelines on optimizing the benefit/risk ratio when switching DMTs in patients with MS.

Keywords: Disease-modifying treatment; French Multiple Sclerosis Society; Guidelines; Multiple Sclerosis; Switch.

MeSH terms

  • Alemtuzumab
  • Cladribine / therapeutic use
  • Fingolimod Hydrochloride / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Multiple Sclerosis* / drug therapy
  • Multiple Sclerosis, Relapsing-Remitting*
  • Natalizumab / therapeutic use

Substances

  • Immunosuppressive Agents
  • Natalizumab
  • Alemtuzumab
  • Cladribine
  • Fingolimod Hydrochloride