Periorbital hypopigmentation and telangiectasias: Clues to diagnosing neonatal lupus in skin of color

Pediatr Dermatol. 2021 Nov:38 Suppl 2:135-136. doi: 10.1111/pde.14674. Epub 2021 Jul 11.

Abstract

Neonatal lupus erythematosus (NLE) is an autoimmune disease characterized by a periorbital erythematous rash. Although post-inflammatory hypopigmentation and telangiectasias are known possible sequelae, these features may be particularly noticeable in skin of color. Herein, we describe two infants with skin of color in whom periorbital hypopigmentation and telangiectasias were clues to the diagnosis of NLE.

Keywords: La antibody; Ro antibody; anti-SS-A; anti-SS-B; anti-U1RNP antibody; hypopigmentation; neonatal lupus erythematosus; periorbital; seborrheic dermatitis; skin of color; telangiectasias; vitiligo.

MeSH terms

  • Antibodies, Antinuclear
  • Ethnic and Racial Minorities
  • Humans
  • Hypopigmentation* / diagnosis
  • Infant
  • Infant, Newborn
  • Lupus Erythematosus, Cutaneous* / diagnosis
  • Lupus Erythematosus, Systemic* / congenital
  • Telangiectasis* / diagnosis
  • Telangiectasis* / etiology

Substances

  • Antibodies, Antinuclear

Supplementary concepts

  • Neonatal Systemic lupus erythematosus