Prognosis of rash and chilblain-like lesions among outpatients with COVID-19: a large cohort study

Eur J Clin Microbiol Infect Dis. 2021 Oct;40(10):2243-2248. doi: 10.1007/s10096-021-04305-3. Epub 2021 Jul 13.

Abstract

In a large regional observational cohort study of adult (≥ 18 years), outpatients with COVID-19, prevalence, characteristics, and outcome of patients with rash and/or chilblain-like lesions (CLL), compared with population without cutaneous features, were studied. In total, 28,957 outpatients were included; the prevalence of rash and CCL were 9.5% and 3.7%, respectively. Presence of rash was significantly associated with presence of asthenia, shivers or myalgia, respiratory and gastro-intestinal symptoms, and anosmia/ageusia. The presence of CCL was associated with chest pain, chest oppression, nausea/vomiting, and anosmia/ageusia. Patients with CCL were significantly less prone to an unfavourable outcome (hospitalization or death).

Keywords: COVID19; Chilblain-like lesion; Hospitalization; Rash; Risk factors.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • COVID-19 / complications*
  • Chilblains / diagnosis
  • Chilblains / etiology*
  • Cohort Studies
  • Exanthema / diagnosis
  • Exanthema / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Outpatients
  • Prognosis
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / physiology