Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization

Signal Transduct Target Ther. 2021 Jul 21;6(1):272. doi: 10.1038/s41392-021-00599-z.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • F-Box Proteins / genetics
  • F-Box Proteins / metabolism*
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Protein Stability
  • Radiation Tolerance*
  • Twist-Related Protein 1 / genetics
  • Twist-Related Protein 1 / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • F-Box Proteins
  • FBXL14 protein, human
  • Neoplasm Proteins
  • Nuclear Proteins
  • TWIST1 protein, human
  • Twist-Related Protein 1
  • Ubiquitin-Protein Ligases