The role of ordered cooperative assembly in biomolecular condensates

Nat Rev Mol Cell Biol. 2021 Oct;22(10):647-648. doi: 10.1038/s41580-021-00408-z.

Abstract

Biomolecular condensates, regardless of whether they exhibit liquid-like properties, are in many cases not fully amorphous, but instead exhibit partial degrees of local structure and order. Here, we discuss how ordered interactions may underlie the cooperative assembly and cellular function of a wide variety of partially ordered macromolecular assemblies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / metabolism
  • Organelles / chemistry
  • Organelles / metabolism
  • Phase Transition
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Signal Transduction / physiology

Substances

  • Multiprotein Complexes
  • Proteins