Heart and Brain Pericytes Exhibit a Pro-Fibrotic Response After Vascular Injury

Thanh T D Pham; Shuin Park; Kamal Kolluri; Riki Kawaguchi; Lingjun Wang; Dana Tran; Peng Zhao; S Thomas Carmichael; Reza Ardehali

doi:10.1161/CIRCRESAHA.121.319288

Heart and Brain Pericytes Exhibit a Pro-Fibrotic Response After Vascular Injury

Circ Res. 2021 Sep 17;129(7):e141-e143. doi: 10.1161/CIRCRESAHA.121.319288. Epub 2021 Aug 17.

Authors

Thanh T D Pham^#^{1

2

3

4}, Shuin Park^#⁴, Kamal Kolluri^#¹, Riki Kawaguchi², Lingjun Wang^{1

5}, Dana Tran², Peng Zhao^{1

3}, S Thomas Carmichael^{2

3

4}, Reza Ardehali^{1

3

4

6}

Affiliations

¹ Cardiology, Internal Medicine (S.P., K.K., L.W., P.Z., R.A.).
² Neurology, David Geffen School of Medicine, UCLA (T.T.D.P., R.K., D.T., S.T.C.).
³ Eli and Edythe Broad Stem Cell Research Center (T.T.D.P., P.Z., S.T.C., R.A.).
⁴ Molecular, Cellular and Integrative Physiology Graduate Program (T.T.D.P., S.P., S.T.C., R.A.).
⁵ Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China (L.W.).
⁶ Molecular Biology Institute, University of California, Los Angeles (R.A.).

^# Contributed equally.

No abstract available

Keywords: brain; fibrosis; heart; ischemic stroke; myocardial infarction; pericytes.

Publication types

Letter

MeSH terms

Animals
Brain / cytology
Brain / metabolism
Brain / pathology
Cell Adhesion Molecules / genetics
Cell Adhesion Molecules / metabolism
Collagen / genetics
Collagen / metabolism
Fibrosis
Mice
Myocardial Infarction / metabolism*
Myocardial Infarction / pathology
Myocardium / cytology
Myocardium / metabolism
Myocardium / pathology
Pericytes / metabolism*
Transcriptome*

Substances

Cell Adhesion Molecules
Postn protein, mouse
Collagen

Grants and funding

R01 NS112256/NS/NINDS NIH HHS/United States