Complete remission of advanced lung adenocarcinoma with first-line pembrolizumab monotherapy: Two case reports

Respir Med Case Rep. 2021 Jul 8:33:101469. doi: 10.1016/j.rmcr.2021.101469. eCollection 2021.

Abstract

Immune checkpoint inhibitors (ICIs) are clinically used for treating advanced lung cancer, and some patients have achieved complete remission (CR) with ICI therapy in clinical trials. However, reports summarizing the clinical courses of such patients are limited. We report two cases of lung adenocarcinoma in which CR was achieved with first-line pembrolizumab monotherapy, and the therapeutic effect was maintained after treatment completion. Specific patients can achieve CR, even those who do not meet the previously reported predictors of treatment response other than high programmed death-ligand 1 expression. Thus, biomarkers that can accurately predict the clinical efficacy of ICIs are warranted.

Keywords: ALK, anaplastic lymphoma kinase; CR, complete remission; CT, computed tomography; Complete remission; EBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; EGFR, epidermal growth factor receptor; ICI, immune checkpoint inhibitors; Immunotherapy; Lung adenocarcinoma; NLR, neutrophil-to-lymphocyte ratio; NSCLC, non-small cell lung cancer; OS, overall survival; PD-L1, programmed death-ligand 1; PR, partial response; Pembrolizumab; RR, response rate; TPS, tumor proportion score.

Publication types

  • Case Reports