Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

Daniel Menia; Holger Kopacka; Klaus Wurst; Thomas Müller; Petra Lippmann; Ingo Ott; Benno Bildstein

doi:10.1002/ejic.202100379

Cobaltoceniumselenolate Gold(I) Complexes: Synthesis, Spectroscopic, Structural and Anticancer Properties

Eur J Inorg Chem. 2021 Jul 22;2021(27):2784-2786. doi: 10.1002/ejic.202100379. Epub 2021 Jun 15.

Authors

Daniel Menia¹, Holger Kopacka¹, Klaus Wurst¹, Thomas Müller², Petra Lippmann³, Ingo Ott³, Benno Bildstein¹

Affiliations

¹ Institute of General, Inorganic and Theoretical Chemistry University of Innsbruck Center for Chemistry and Biomedicine Innrain 80-82 6020 Innsbruck Austria.
² Institute of Organic Chemistry University of Innsbruck Center for Chemistry and Biomedicine Innrain 80-82 6020 Innsbruck Austria.
³ Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig Beethovenstr. 55 38106 Braunschweig Germany.

Abstract

Cobaltoceniumselenolate is an unusual, highly air-sensitive, mesoionic compound containing a very soft anionic selenium donor atom. Here we explore its coordination chemistry with Au(I) metal centers and show that its hetero- and homoleptic gold complexes are highly colored, air-stable compounds, which were characterized by ¹H/¹³C/³¹P/⁷⁷Se NMR, IR, UV-Vis, HR-MS and single crystal XRD. Cytotoxicity of these polar, water-soluble complexes was studied against various standard cancer cell lines (A549MDA-MB-231, HT-29) revealing good anticancer activity of all three complexes.

Keywords: Cobalt; Cytotoxicity; Gold; Sandwich complexes; Selenium.