New bisabolane-type phenolic sesquiterpenoids from the marine sponge Plakortis simplex

Chin J Nat Med. 2021 Aug;19(8):626-631. doi: 10.1016/S1875-5364(21)60062-6.

Abstract

Six new bisabolane-type phenolic sesquiterpenoids, including plakordiols A-D (1-4), (7R, 10R)-hydroxycurcudiol (5) and (7R, 10S)-hydroxycurcudiol (6) were isolated from the marine sponge Plakortis simplex collected from the South China Sea. Their structures were determined based on extensive analysis of spectroscopic data. Their configurations were assigned by coupling constant analysis, NOESY correlations, and the modified Mosher's method. Furthermore, their cytotoxic and antibacterial activities were evaluated.

Keywords: Marine sponge; Plakordiols; Plakortis simplex; Sesquiterpene phenols.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • China
  • Molecular Structure
  • Monocyclic Sesquiterpenes* / pharmacology
  • Pacific Ocean
  • Plakortis* / chemistry

Substances

  • Anti-Bacterial Agents
  • Monocyclic Sesquiterpenes