Advances of Endothelial Progenitor Cells in the Development of Depression

Nana Yang; Shiyu Sun; Guangqing Duan; Kaixuan Lv; Chen Liang; Linlin Zhang; Jielun Yu; Yaohui Tang; Guohua Lu

doi:10.3389/fncel.2021.608656

Advances of Endothelial Progenitor Cells in the Development of Depression

Front Cell Neurosci. 2021 Aug 5:15:608656. doi: 10.3389/fncel.2021.608656. eCollection 2021.

Authors

Nana Yang^{1

2}, Shiyu Sun¹, Guangqing Duan³, Kaixuan Lv¹, Chen Liang⁴, Linlin Zhang¹, Jielun Yu^{1

2}, Yaohui Tang⁵, Guohua Lu⁶

Affiliations

¹ School of Bioscience and Technology, Weifang Medical University, Weifang, China.
² Medical Laboratory Animal Center, Weifang Medical University, Weifang, China.
³ School of Clinical Medicine, Weifang Medical University, Weifang, China.
⁴ School of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, China.
⁵ Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
⁶ School of Psychology, Weifang Medical University, Weifang, China.

Abstract

Depression is a major psychological disease of human beings. With the severity of depression, it elevates the risk of cardiovascular disease (CVD), especially acute coronary syndrome (ACS), resulting in serious harm to human health. The number of endothelial progenitor cells (EPCs) is closely related to the development of depression. It has been reported that the number of peripheral blood EPCs in patients with depression was reduced. However, effects on the function of EPCs in depression are still unclear. This paper aims to analyze and summarize the research of EPCs in depression, and we envision that EPCs might act as a new target for evaluating the severity of depression and its complications.

Keywords: TNF-α; cardiovascular disease; depression; endothelial progenitor cells; psychological disease.

Publication types

Review