Hemolytic Anemia after Acute Hepatitis B Virus Infection: A Case Report and Systematic Review

Intern Med. 2022 Feb 15;61(4):481-488. doi: 10.2169/internalmedicine.7690-21. Epub 2021 Aug 24.

Abstract

Hemolytic anemia and pure red cell aplasia are rare hematological complications of hepatitis B virus infection. We herein report a 24-year-old man who was diagnosed with hemolytic anemia and possible transient pure red cell anemia eight weeks after a severe episode of acute hepatitis B virus infection. Rapid recovery was observed with conservative management. Hemoglobin returned to baseline within three months. As the clinical features of hemolytic anemia associated with hepatitis B virus have not yet been elucidated, we conducted a systematic review and present an analysis of the 20 reported cases, including our present case.

Keywords: hemolytic anemia; hepatitis B virus; liver failure; pure red cell aplasia; systematic review.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adult
  • Anemia, Hemolytic* / complications
  • Anemia, Hemolytic* / etiology
  • Anemia, Hemolytic, Autoimmune* / complications
  • Hepatitis B* / complications
  • Hepatitis B* / diagnosis
  • Humans
  • Male
  • Red-Cell Aplasia, Pure* / complications
  • Young Adult