Macrophage metabolic regulation in atherosclerotic plaque

Atherosclerosis. 2021 Oct:334:1-8. doi: 10.1016/j.atherosclerosis.2021.08.010. Epub 2021 Aug 17.

Abstract

Metabolism plays a key role in controlling immune cell functions. In this review, we will discuss the diversity of plaque resident myeloid cells and will focus on their metabolic demands that could reflect on their particular intraplaque localization. Defining the metabolic configuration of plaque resident myeloid cells according to their topologic distribution could provide answers to key questions regarding their functions and contribution to disease development.

Keywords: Atherosclerosis; Foamy cells; Glucose; Immunometabolism; Macrophage; Monocyte.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Atherosclerosis*
  • Humans
  • Macrophages
  • Plaque, Atherosclerotic*