Nonbone Marrow CD34+ Cells Are Crucial for Endothelial Repair of Injured Artery

Circ Res. 2021 Oct;129(8):e146-e165. doi: 10.1161/CIRCRESAHA.121.319494. Epub 2021 Sep 3.

Abstract

[Figure: see text].

Keywords: CD34 antigens; RNA sequence analysis; endothelial cells; fluorescent antibody technique; microRNAs; smad proteins; vascular system injuries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD34 / genetics
  • Antigens, CD34 / metabolism
  • Cell Differentiation
  • Cells, Cultured
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiology
  • Female
  • Femoral Artery / injuries
  • Femoral Artery / metabolism
  • Femoral Artery / physiology*
  • Humans
  • Male
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Regeneration*
  • Smad Proteins / genetics
  • Smad Proteins / metabolism

Substances

  • Antigens, CD34
  • MIRN21 microRNA, mouse
  • MicroRNAs
  • Smad Proteins