Lymphomatoid granulomatosis of the central nervous system (CNS-LYG) posing a management challenge

Mohsin Soleja; Jesse Manuel Jaso; Weina Chen; Jack Raisanen; Christian A Wysocki; Yu-Min Shen; Bruce Mickey; Kiran A Kumar; Praveen Ramakrishnan Geethakumari

doi:10.1002/ccr3.4808

Lymphomatoid granulomatosis of the central nervous system (CNS-LYG) posing a management challenge

Clin Case Rep. 2021 Sep 7;9(9):e04808. doi: 10.1002/ccr3.4808. eCollection 2021 Sep.

Authors

Mohsin Soleja¹, Jesse Manuel Jaso², Weina Chen², Jack Raisanen², Christian A Wysocki³, Yu-Min Shen¹, Bruce Mickey⁴, Kiran A Kumar⁵, Praveen Ramakrishnan Geethakumari¹

Affiliations

¹ Division of Hematologic Malignancies and Cellular Therapy, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas TX USA.
² Department of Pathology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USA.
³ Division of Allergy and Immunology, Department of Internal Medicine UT Southwestern Medical Center Dallas TX USA.
⁴ Department of Neurosurgery Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USA.
⁵ Department of Radiation Oncology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USA.

Abstract

Isolated central nervous system lymphomatoid granulomatosis (CNS-LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS-LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra-low-dose radiation therapy.

Keywords: EBV‐associated B‐cell lymphoproliferative disorder; Epstein‐Barr virus; immune thrombocytopenia; lymphomatoid granulomatosis; pulmonary embolism; thrombosis.

Publication types

Case Reports