Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

Emerg Infect Dis. 2021 Nov;27(11):2914-2918. doi: 10.3201/eid2711.211612. Epub 2021 Sep 29.

Abstract

We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology of this syndrome, regardless of vaccination status, remains poorly understood.

Keywords: COVID-19; MIS-A; SARS-CoV-2; coronavirus disease; multisystem inflammatory syndrome in adults; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine-preventable diseases; vaccines; viruses.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • SARS-CoV-2
  • Syndrome
  • Vaccination

Substances

  • COVID-19 Vaccines