Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors

Amy M Berkman; Clark R Andersen; Vidya Puthenpura; J A Livingston; Sairah Ahmed; Branko Cuglievan; Michelle A T Hildebrandt; Michael E Roth

doi:10.1016/j.canep.2021.102044

Disparities in the long-term survival of adolescent and young adult diffuse large B cell lymphoma survivors

Cancer Epidemiol. 2021 Dec:75:102044. doi: 10.1016/j.canep.2021.102044. Epub 2021 Sep 28.

Authors

Amy M Berkman¹, Clark R Andersen², Vidya Puthenpura³, J A Livingston⁴, Sairah Ahmed⁵, Branko Cuglievan⁶, Michelle A T Hildebrandt⁷, Michael E Roth⁸

Affiliations

¹ Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
² Division of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Section of Pediatric Hematology and Oncology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
⁴ Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁶ Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁷ Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁸ Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: MRoth1@MDAnderson.org.

Abstract

Purpose: The population of adolescent and young adult (AYA, ages 15-39 years) diffuse large B-cell lymphoma (DLBCL) survivors is growing, however long-term overall survival patterns and disparities are largely unknown.

Methods: The current study utilized the Surveillance, Epidemiology, and End Results (SEER) registry to assess the impact of race/ethnicity, sex, socioeconomic status, and rurality on long-term survival in 5-year DLBCL survivors using an accelerated failure time model.

Results: Included were 4767 5-year survivors of AYA DLBCL diagnosed between the years 1980 and 2009 with a median follow-up time of 13.4 years. Non-Hispanic Black survivors had significantly worse long-term survival than non-Hispanic White survivors (Survival Time Ratio (STR): 0.53, p < 0.0001). Male sex (STR: 0.57, p < 0.0001) and older age at diagnosis were also associated with reduced long-term survival. There was no evidence that survival disparities improved over time.

Conclusions: Racial disparities persist well into survivorship among AYA DLBCL survivors. Studies investigating specific factors associated with survival disparities are urgently needed to better address these disparities.

Keywords: AYA; Adolescent and Young Adult Oncology; Diffuse large B-cell lymphoma; Racial disparities; Survival.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Ethnicity
Humans
Lymphoma, Large B-Cell, Diffuse* / epidemiology
Male
SEER Program
Social Class
Survivors
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding