Chronic recurrent multifocal osteomyelitis, central retinal artery occlusion and optic neuropathy: A new association

Michael S Vaphiades; Kevin E Lai; Lanning B Kline; Brendan Grondines; Emily Riser

doi:10.1016/j.ajoc.2021.101209

Chronic recurrent multifocal osteomyelitis, central retinal artery occlusion and optic neuropathy: A new association

Am J Ophthalmol Case Rep. 2021 Sep 21:24:101209. doi: 10.1016/j.ajoc.2021.101209. eCollection 2021 Dec.

Authors

Michael S Vaphiades^{1

2}, Kevin E Lai^{3

4

5}, Lanning B Kline¹, Brendan Grondines¹, Emily Riser²

Affiliations

¹ Departments of Ophthalmology, University of Alabama, Birmingham, AL, USA.
² Departments of Neurology, University of Alabama, Birmingham, AL, USA.
³ Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴ Ophthalmology Service, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.
⁵ Neuro-Ophthalmology Section, Midwest Eye Institute, Carmel, IN, USA.

Abstract

Purpose: To report a patient with chronic recurrent multifocal osteomyelitis (CRMO) complicated by optic neuropathy and central retinal artery occlusion (CRAO).

Observations: CRMO is a noninfectious, inflammatory bone disorder. It is thought to be an autoimmune condition related to an imbalance of pro- and anti-inflammatory cytokines. Retinal vasculitis has been reported in a patient with CRMO but not CRAO or optic neuropathy.

Conclusions: We expanded the list of ophthalmic involvement of CRMO to include CRAO and optic neuropathy.

Keywords: Central retinal artery occlusion; Chronic recurrent multifocal osteomyelitis; Optic neuropathy.

Publication types

Case Reports