Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric Illness: A Case Report

Verinder Sharma; Sapna Sharma; Minakshi Doobay

doi:10.2174/1574886316666211013120735

Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric Illness: A Case Report

Curr Drug Saf. 2022;17(3):278-280. doi: 10.2174/1574886316666211013120735.

Authors

Verinder Sharma¹, Sapna Sharma², Minakshi Doobay³

Affiliations

¹ Department of Psychiatry, Western University, Ontario, ON, Canada.
² Department of Obstetrics and Gynecology, Mc- Master University, Ontario, ON, Canada.
³ Department of Medicine, Western University, Ontario, ON, Canada.

PMID: 34645378
DOI: 10.2174/1574886316666211013120735

Abstract

Background: In this report, we describe a case of domperidone withdrawal in a woman with a history of major depressive disorder and obsessive-compulsive disorder (OCD), who experienced a recurrence of these disorders after stopping domperidone.

Case presentation: The symptoms improved after the restarting of domperidone and disappeared gradually as the drug was tapered and discontinued. Clinicians should consider domperidone withdrawal a differential diagnosis in women with a history of depression or anxiety who present with an acute onset of these symptoms following the abrupt discontinuation of domperidone.

Conclusion: A gradual taper off of the drug may be effective in minimizing withdrawal symptoms and obviate the need for psychotropic drug use.

Keywords: Domperidone; OCD; depression; galactagogue; lactation; withdrawal-induced.

Publication types

Case Reports

MeSH terms

Anxiety Disorders / epidemiology
Anxiety Disorders / psychology
Comorbidity
Depressive Disorder, Major* / diagnosis
Depressive Disorder, Major* / drug therapy
Depressive Disorder, Major* / epidemiology
Domperidone / adverse effects
Female
Humans
Obsessive-Compulsive Disorder* / diagnosis
Obsessive-Compulsive Disorder* / epidemiology
Obsessive-Compulsive Disorder* / psychology

Substances

Domperidone