Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice

Hypertension. 2021 Dec;78(6):1760-1770. doi: 10.1161/HYPERTENSIONAHA.121.17643. Epub 2021 Oct 18.

¹ Department of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa.
² Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China (X.W.).
³ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China (Y.C., L.Z.).
⁴ College of Medicine, College of Public Health (L.X.), University of South Florida, Tampa.
⁵ Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Research Institute, Tampa, FL (K.J.).
⁶ Department of Pharmaceutical Science, College of Pharmacy (F.C.), University of South Florida, Tampa.
⁷ Department of Urology (T.P.), University of South Florida, Tampa.
⁸ Advanced Organ Disease and Transplantation Institute, Tampa General Hospital, FL (J.B.).
⁹ Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA (V.V.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: diabetes mellitus; glomerular filtration rate; hemodynamics; hypertension; kidney; nitric oxide; nitric oxide synthase.