Astrocyte interleukin-3 preps microglia

Trends Immunol. 2021 Nov;42(11):937-939. doi: 10.1016/j.it.2021.09.008. Epub 2021 Oct 14.

Abstract

Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aβ endows microglia with enhanced capability to cluster and clear Aβ oligomers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease*
  • Amyloid beta-Peptides / metabolism
  • Astrocytes
  • Humans
  • Interleukin-3 / metabolism
  • Microglia*

Substances

  • Amyloid beta-Peptides
  • Interleukin-3