Targeted Anti-Tumor Immunotherapy Using Tumor Infiltrating Cells

Abstract

In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti-tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor-infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti-tumor immune response to certain groups of patients. Herein, the recent research progress on tumor-infiltrating B cells and T cells, including CD8⁺ T cells, CD4⁺ T cells, and exhausted T cells and their role in anti-tumor immunity, is summarized. Moreover, several anti-tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.

Keywords: B cells; CD4+ T cells; CD8+ T cells; T-cell exhaustion; anti-tumor immunity; anti-tumor therapy; tumor immunotherapy; tumor microenvironment.