Decomposing the mutational landscape of cancer genomes with RepairSig

Sara Bernardo; Mathilde Meyenberg; Joanna I Loizou

doi:10.1016/j.cels.2021.09.009

Decomposing the mutational landscape of cancer genomes with RepairSig

Cell Syst. 2021 Oct 20;12(10):953-955. doi: 10.1016/j.cels.2021.09.009.

Authors

Sara Bernardo¹, Mathilde Meyenberg², Joanna I Loizou³

Affiliations

¹ Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address: sara.bernardo@meduniwien.ac.at.
² Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
³ Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Centre, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. Electronic address: joanna.loizou@meduniwien.ac.at.

PMID: 34672958
DOI: 10.1016/j.cels.2021.09.009

Abstract

Mutational signatures are the outcomes of mutagenic processes that occur prior to, and during, tumorigenesis as a result of DNA damage, DNA repair, and DNA replication. In this issue of Cell Systems, Wojtowicz et al. introduce a new computational model aimed at deconstructing the mutational processes that shape cancer genomes.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

DNA Damage / genetics
DNA Repair / genetics
Genome, Human / genetics
Humans
Mutation / genetics
Neoplasms* / genetics