Interferon induction held captive in tumor cells

Mol Cell. 2021 Oct 21;81(20):4109-4110. doi: 10.1016/j.molcel.2021.10.004.

Abstract

Unusual nucleic acids activate innate immunity and may be present in transformed cells. Meng et al. (2021) find that cancer-associated mutations in NF2 turn this tumor suppressor into a potent antagonist of DNA- and RNA-induced innate immune signaling.

Publication types

  • Comment

MeSH terms

  • Immunity, Innate
  • Interferons*
  • Nucleic Acids*
  • RNA
  • Signal Transduction

Substances

  • Nucleic Acids
  • RNA
  • Interferons