Resolvin E1 Attenuates Pulmonary Hypertension by Suppressing Wnt7a/β-Catenin Signaling

Hypertension. 2021 Dec;78(6):1914-1926. doi: 10.1161/HYPERTENSIONAHA.121.17809. Epub 2021 Oct 25.

Guizhu Liu^#¹, Naifu Wan^#², Qian Liu^#³, Yuqin Chen¹, Hui Cui⁴, Yuanyang Wang³, Jiaoqi Ren⁵, Xia Shen^{4

6}, Wenju Lu¹, Ying Yu^#^{1

3

6}, Yujun Shen^#³, Jian Wang^#^{1

7}

¹ From the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (G.L., Y.C., W.L., Y.Y., J.W.).
² Department of Cardiology, Ruijin Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China (N.W.).
³ Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China (Q.L., Y.W., Y.Y., Y.S.).
⁴ School of Life Science and Technology, Shanghai Tech University, Shanghai, China (H.C., X.S.).
⁵ Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, China (J.R.).
⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China (X.S., Y.Y.).
⁷ Department of Medicine, University of California, San Diego, La Jolla (J.W.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: ChemR23; PASMCs; Resolvin E1; Wnt7a; pulmonary arterial hypertension.