A genetic model for the secretory stage of dental enamel formation

James P Simmer; Jan C-C Hu; Yuanyuan Hu; Shelly Zhang; Tian Liang; Shih-Kai Wang; Jung-Wook Kim; Yasuo Yamakoshi; Yong-Hee Chun; John D Bartlett; Charles E Smith

doi:10.1016/j.jsb.2021.107805

A genetic model for the secretory stage of dental enamel formation

J Struct Biol. 2021 Dec;213(4):107805. doi: 10.1016/j.jsb.2021.107805. Epub 2021 Oct 27.

Authors

James P Simmer¹, Jan C-C Hu², Yuanyuan Hu³, Shelly Zhang⁴, Tian Liang⁵, Shih-Kai Wang⁶, Jung-Wook Kim⁷, Yasuo Yamakoshi⁸, Yong-Hee Chun⁹, John D Bartlett¹⁰, Charles E Smith¹¹

Affiliations

¹ Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA. Electronic address: jsimmer@umich.edu.
² Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA. Electronic address: janhu@umich.edu.
³ Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA. Electronic address: yyhu@umich.edu.
⁴ Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA. Electronic address: shellyhuzhang@gmail.com.
⁵ Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA. Electronic address: tianl@umich.edu.
⁶ Department of Dentistry, National Taiwan University School of Dentistry, No. 1, Changde St., Zhongzheng Dist., Taipei City 100, Taiwan; Department of Pediatric Dentistry, National Taiwan University Children's Hospital, No. 8, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 100, Taiwan. Electronic address: shihkaiw@ntu.edu.tw.
⁷ Department of Molecular Genetics, School of Dentistry & Dental Research Institute, Seoul National University, Seoul, Korea; Department of Pediatric Dentistry, School of Dentistry & Dental Research Institute, Seoul National University, Seoul, Korea. Electronic address: pedoman@snu.ac.kr.
⁸ Department of Biochemistry and Molecular Biology, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. Electronic address: yamakoshi-y@tsurumi-u.ac.jp.
⁹ Department of Periodontics, School of Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Electronic address: chuny@uthscsa.edu.
¹⁰ Division of Biosciences, Ohio State University College of Dentistry, Columbus, OH, USA. Electronic address: bartlett.196@osu.edu.
¹¹ Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI 48108, USA; Department of Anatomy & Cell Biology, Faculty of Medicine & Health Sciences, McGill University, Montreal, Quebec H3A 0C7, Canada. Electronic address: charles.smith@mcgill.ca.

Abstract

The revolution in genetics has rapidly increased our knowledge of human and mouse genes that are critical for the formation of dental enamel and helps us understand how enamel evolved. In this graphical review we focus on the roles of 41 genes that are essential for the secretory stage of amelogenesis when characteristic enamel mineral ribbons initiate on dentin and elongate to expand the enamel layer to the future surface of the tooth. Based upon ultrastructural analyses of genetically modified mice, we propose a molecular model explaining how a cell attachment apparatus including collagen 17, α6ß4 and αvß6 integrins, laminin 332, and secreted enamel proteins could attach to individual enamel mineral ribbons and mold their cross-sectional dimensions as they simultaneously elongate and orient them in the direction of the retrograde movement of the ameloblast membrane.

Keywords: ACP4; Amelogenesis; Basement membrane; Biomineralization; Evolution; SLC13A5.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Ameloblasts / cytology
Ameloblasts / metabolism*
Ameloblasts / ultrastructure
Amelogenesis / genetics*
Animals
Collagen / genetics
Collagen / metabolism
Dental Enamel / cytology
Dental Enamel / metabolism*
Dental Enamel Proteins / genetics*
Dental Enamel Proteins / metabolism
Humans
Integrins / genetics
Integrins / metabolism
Laminin / genetics
Laminin / metabolism
Mice
Microscopy, Electron, Scanning / methods
Models, Genetic*

Substances

Dental Enamel Proteins
Integrins
Laminin
Collagen

Abstract

Publication types

MeSH terms

Substances

Grants and funding