Oxazaborolidinone-Mediated Asymmetric Bisvinylogous Mukaiyama Aldol Reaction

Org Lett. 2021 Nov 19;23(22):8722-8726. doi: 10.1021/acs.orglett.1c03165. Epub 2021 Nov 5.

Abstract

A bisvinylogous Mukaiyama aldol reaction using oxazaborolidinones as a source of chirality was developed. This methodology allows the fast assembly of conjugated dienols by expanding the vinylogy principle by two additional carbons, and can be conducted using a readily available Lewis acid at reasonable reaction times. A broad range of aromatic and aliphatic aldehydes can be used providing access to complex building blocks for polyketide synthesis.

Publication types

  • Research Support, Non-U.S. Gov't