Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer

Leah H Biller; Siobhan A Creedon; Margaret Klehm; Matthew B Yurgelun

doi:10.1016/j.giec.2021.08.002

Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer

Gastrointest Endosc Clin N Am. 2022 Jan;32(1):75-93. doi: 10.1016/j.giec.2021.08.002.

Authors

Leah H Biller¹, Siobhan A Creedon², Margaret Klehm², Matthew B Yurgelun³

Affiliations

¹ Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Brigham & Women's Hospital, Boston, MA 02215, USA.
² Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
³ Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02215, USA; Brigham & Women's Hospital, Boston, MA 02215, USA. Electronic address: matthew_yurgelun@dfci.harvard.edu.

PMID: 34798988
DOI: 10.1016/j.giec.2021.08.002

Abstract

Lynch syndrome (LS) is a common form of inherited cancer susceptibility, which predisposes to colorectal cancer (CRC) along with a wide array of other extracolonic malignancies, including other gastrointestinal cancers, cancers of the gynecologic and genitourinary tracts, and other organ sites. Recent data have provided novel insights into patient-specific factors that can help clinicians understand an individual LS carrier's risk of extracolonic cancers, including sex, specific LS gene, age, family history of cancer, and other factors. This summary seeks to provide an update on extracolonic cancer risks in LS and provide recommendations for surveillance and risk reduction.

Keywords: Extra-colonic; HNPCC; Screening.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms* / etiology
Colorectal Neoplasms, Hereditary Nonpolyposis* / complications
Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
Female
Genetic Predisposition to Disease
Humans
Surveys and Questionnaires