The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Zhigang Li; Qingyu Guo; Jiaxin Zhang; Zitong Fu; Yifei Wang; Tianzhen Wang; Jing Tang

doi:10.3389/fonc.2021.757135

The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Front Oncol. 2021 Nov 4:11:757135. doi: 10.3389/fonc.2021.757135. eCollection 2021.

Authors

Zhigang Li¹, Qingyu Guo², Jiaxin Zhang², Zitong Fu², Yifei Wang³, Tianzhen Wang², Jing Tang²

Affiliations

¹ Department of Orthopedics, Affiliated Hospital of Chifeng University, Chifeng, China.
² Department of Pathology, Harbin Medical University, Harbin, China.
³ Department of Urology, Hainan General Hospital, Hainan, China.

Abstract

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.

Keywords: RNA binding protein; RNA-binding motif protein; cancer; prognosis; tumorigenesis.

Publication types

Review