Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area

Andrew Tirsi; Vasiliki Gliagias; Julie Moehringer; Derek Orshan; Sofia Tello; Peter Derr; Sung Chul Park; Stephen A Obstbaum; Celso Tello

doi:10.1155/2021/8025337

Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area

J Ophthalmol. 2021 Oct 13:2021:8025337. doi: 10.1155/2021/8025337. eCollection 2021.

Authors

Andrew Tirsi^{1

2}, Vasiliki Gliagias², Julie Moehringer³, Derek Orshan⁴, Sofia Tello⁵, Peter Derr⁶, Sung Chul Park^{1

2}, Stephen A Obstbaum^{1

2}, Celso Tello^{1

2}

Affiliations

¹ Manhattan Eye Ear and Throat Hospital, New York, NY 10065, USA.
² Donald and Barbara Zucker School of Medicine at Hofstra University/Northwell Health, Hempstead, NY 11549, USA.
³ Sandford H. Calhoun High School, Merrick, NY 11566, USA.
⁴ New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11545, USA.
⁵ Rye High School, Rye, NY 10580, USA.
⁶ Diopsys Inc., Pine Brook, NJ 07058, USA.

Abstract

Purpose: We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area.

Methods: Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch's membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area.

Results: Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p ≤ 0.004). All pattern electroretinogram parameters significantly correlated with Bruch's membrane opening-minimum rim width sectors-temporal superior and nasal inferior (r = 0.400, p=0.039)-and retinal nerve fiber layer sectors-superior, nasal superior, and inferior (r ≥ 0.428, p ≤ 0.026). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p=0.003, and B = 0.160 (95% CI: 0.056, 0.265), p=0.004), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch's membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p=0.031, and B = 129.024 (95% CI: 9.589, 248.460), p=0.035), respectively. All Bruch's membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p ≤ 0.045).

Conclusion: PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma.