Type IX collagen is a potent inducer of PGE2 and interleukin 1 production by human monocyte macrophages

FEBS Lett. 1986 Mar 31;198(2):208-12. doi: 10.1016/0014-5793(86)80406-9.

Abstract

Type IX collagen and its collagenous fragments are potent stimulatory agents on human blood mononuclear cells for the production of prostaglandin E2 and interleukin 1/mononuclear cell factor. Type IX collagen is 2-4-fold more potent that type I and II and 1 alpha-, 2 alpha- and 3 alpha-collagens. This property may be important in the destructive process of cartilage in inflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Collagen / pharmacology*
  • Dinoprostone
  • Humans
  • Interleukin-1 / biosynthesis*
  • Macrophages / metabolism*
  • Monocytes / drug effects
  • Monocytes / metabolism*
  • Monokines
  • Prostaglandins E / biosynthesis*
  • Protein Biosynthesis

Substances

  • Interleukin-1
  • Monokines
  • Prostaglandins E
  • Collagen
  • Dinoprostone