Clinical significance of a novel reticulocyte-based erythropoietin resistance index in HD patients: A retrospective study

Abstract

Introduction: The erythropoietin resistance index (ERI) is an indicator of erythropoiesis-stimulating agent (ESA) responsiveness and is typically calculated using Hb. However, Hb does not directly reflect ESA-induced erythropoiesis because of its long-term nature. We thus designed a novel ERI calculated with reticulocyte Hb (RetHb), a real-time index, and investigated its association with mortality in HD patients.

Methods: We calculated the ERI using the change in RetHb before and after ESA administration (ERI_ΔRetHb ) and retrospectively analyzed its association with 3-year all-cause mortality using Kaplan-Meier survival curves and Cox regression analyses.

Results: A total of 102 patients were included. Patients with the highest ERI_ΔRetHb had the worst prognosis according to the Kaplan-Meier survival curves (Log-rank p = 0.02). Multivariate Cox regression analysis showed that the ERI_ΔRetHb was significantly and independently associated with all-cause mortality (hazard ratio: 9.82, 95% CI [1.50, 64.41], p = 0.02).

Conclusion: The ERI_ΔRetHb was significantly and independently associated with all-cause mortality in HD patients.

Keywords: ESA; HD; erythropoietin resistance index; prognosis; reticulocyte.