Truly Man's Best Friend: Canine Cancers Drive Drug Repurposing in Osteosarcoma

Clin Cancer Res. 2022 Feb 15;28(4):571-572. doi: 10.1158/1078-0432.CCR-21-3471.

Abstract

While metastatic osteosarcoma is rare in humans, it is the most common bone tumor found in any breed of dog. Given the genetic similarities between canine and human osteosarcomas, canine clinical trials allow for rapid testing and drug repurposing at a speed that cannot be achieved using patients with osteosarcoma. See related article by Regan et al., p. 662.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Bone Neoplasms* / drug therapy
  • Bone Neoplasms* / genetics
  • Bone Neoplasms* / veterinary
  • Dog Diseases* / drug therapy
  • Dog Diseases* / genetics
  • Dog Diseases* / pathology
  • Dogs
  • Drug Repositioning
  • Humans
  • Osteosarcoma* / drug therapy
  • Osteosarcoma* / genetics
  • Osteosarcoma* / pathology